Lovo works with
any manufacturing process.

Select an application
  • Immunomagnetic Selection Prep
  • Fresh Leukapheresis Wash
  • Culture Harvest & Media Exchange
  • Thawed Wash & DMSO Removal
Applications

Immunomagnetic Selection Prep

Lovo can automate preparation for magnetic selections, simplifying and expediting day 0 processing. With Lovo 3.0 software, you have the option to incorporate mid-procedure, timed incubations in your protocol design.

  • Overview
  • Data
Measure Result
Source Products Collections n=5
Volume 163.3 ± 28.5 mL
Total Nucleated Cells (TNC) 10.9 ± 3.4 x 109
Platelet Count 4.46 ± 0.92 x 10 11
Processing Time Automated Processing Time (With incubation) 58 minutes
Max Processing Time 61 minutes

Source: LOVO 2.X Blood Run Protocol Report: 223-DER-048957 – Data on file at Fresenius Kabi USA.

Measure Result
2 wash cycles to remove platelets and prepare for incubation Platelet Depletion 98.4 ± 1.0%
Targeted Pre-Incubation Volume 100 mL
Actual Pre-Incubation Volume 100.6 ± 1.2 mL
Full Procedure TNC recovery 97.2 ± 3.7%
TNC Viability 96.3 ± 1.4%

Source: LOVO 2.X Blood Run Protocol Report: 223-DER-048957 – Data on file at Fresenius Kabi USA.

Applications

Fresh Leukapheresis Wash

Quickly and easily remove platelets from leukapheresis products while recovering TNCs and maintaining cell viability.

  • Overview
  • Data
Measure Result
Collections
(5L)
Fenwal Amicus n=6
Spectra Optia n=8
Source Volume 90.8 ± 10.2 ml
TNC 4.7 ± 1.8 x 109
Final
Product
TNC Recovery 98.6%
TNC Viability 97.5%
Target Final Volume 95 mL
Actual Final Volume 95.3 ± 0.6 mL
Processing Time Average 11:01 min
Maximum 11:29 min

Source: LOVO 2.X Product Quality Test Results Design Review: 223-DER-048958 – Data on file at Fresenius Kabi USA.

Pre/Post Lovo Wash Platelet Count & Depletion

Source: LOVO 2.X Product Quality Test Results Design Review: 223-DER-048958 – Data on file at Fresenius Kabi USA.

Applications

Culture Harvest & Media Exchange

Quickly and easily wash and concentrate up to 22L of cultured cells in one automated and functionally closed system.

Study objective

  • Compare T-Cell harvest methods

Goals

  • Reduce volume from 1.7L to 150mL
  • >99% (2 log) reduction of ancillary materials
  • High cell recovery
  • Maintain cellular CQAs
Cell Type Lovo
Fresenius Kabi
CS5+
Haemonetics
Manual
Recovery (%) 93 ± 4 87 ± 3 91 ± 4
Processing Time (min) 30 ± 1 25 ± 4 61 ± 11
Washout Efficiency (%) 99.5 99.9 99.8
Final Volume (mL) 150 ± 1 153 ± 3 151 ± 6
Cellular CQAs1 comparable
Automated ± x
Functionally Closed ± x

1 Critical Quality Attributes (CQAs) Measured: viability assessment, phenotype, cell functionality, ancillary materials.

Source: Lovo New Membrane Cultured Cell Testing Results: 223-DER-066723 – Data on file at Fresenius Kabi USA.

Applications

Thawed Wash & DMSO Removal

Wash cryopreserved products and resuspend cells in your preferred buffer or culture media.

  • Overview
  • Data
Measure Lovo 2.0
(three-cycle)
Number of Runs 6
PCV% 8.4% (6.9 - 11.4)
Viable CD34+ Cell Recovery 84% (61 - 93)
CD34+ Cell Viability 92% (81 - 94)
DMSO Elimination 97% (97 - 98)
Total Processing Time 62 min

† Data is expressed as median and (IQR)

Source: B.Mfarrej, et al. Pre-clinical assessment of the Lovo device for dimethyl sulfoxide removal and cell concentration in thawed hematopoietic progenitor cell grafts. Cytotherapy, Volume 19, Issue 12, 1501-1508.

3-Cycle Wash1

Post Thaw Recovery

Source: B.Mfarrej, et al. Pre-clinical assessment of the Lovo device for dimethyl sulfoxide removal and cell concentration in thawed hematopoietic progenitor cell grafts. Cytotherapy, Volume 19, Issue 12, 1501-1508.

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The Lovo Cell Processing System is for laboratory use only and may not be used for direct transfusion. Appropriate regulatory clearance is required by the user for clinical use.

For applications requiring regulatory clearance or approval, Users may request required Lovo technical documentation from Fresenius Kabi to support their submission.

Refer to the Lovo Cell Processing System Operator’s Manual for a complete list of warnings and precautions associated with the use these products.